Anti-Centromere Ab |
Anti-Centromere Ab by IFA (RDL) |
This test is a component of ANA Profile 11, ANA 12 Profile, ANA 12 Plus Profile, Scleroderma Comprehensive Profile, Scleroderma Comprehensive Profile Plus.
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
14 - 21 days 14 - 21 days |
14 - 21 days 14 - 21 days |
Serum
1 mL
0.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Refrigerate or freeze.
Temperature | Period |
---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
The most common setting for finding anti-centromere antibodies is in patients with a limited cutaneous form of scleroderma. Anti-centromere abs are found in 22% of patients with systemic sclerosis and in 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals.
Indirect fluorescent antibody (IFA)
Anti-centromere abs are found in 46% of patients with Limited Systemic Sclerosis and 11% in Diffuse Systemic Sclerosis, as well as 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals. The antibodies are associated with CREST syndrome.
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
520065 | Anti-Centromere Ab (RDL) | 5077-3 | 520066 | Anti-Centromere Ab (RDL) | 5077-3 |
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